1239196-89-4

Upstream product

• 52721-69-4 [2-(2-fluorophenyl)ethyl]amine 
• 152628-03-0 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid 

Downstream Products

• 1261266-19-6 4'-[[6-(2-(2'-fluoro)phenethylamino)carbonyl-4-methyl-2-propyl-1H-benzimidazolyl]methyl]-2-biphenylcarboxylic acid 
• 1261266-01-6 methyl 4'-[[6-(2'-fluoro)phenethylaminocarbonyl-4-methyl-2-propyl-1H-benzimidazolyl]methyl]biphenyl-2-carboxylate 
• 1390645-46-1 N-(2-fluorophenethyl)-1-([2'-(1-triphenylmethyltetrazol-5-yl)-(1,1'-biphenyl)-4-yl]methyl)-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide 
• 1390645-37-0 N-(2-fluorophenethyl)-1-([2'-(1H-tetrazol-5-yl)-(1,1'-biphenyl)-4-yl]methyl)-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazole derivatives as nonpeptidic angiotensin II AT1 receptor antagonists

A series of 6-substituted aminocarbonyl benzimidazole derivatives were designed and synthesized as nonpeptidic angiotensin II AT1 receptor antagonists. The preliminary pharmacological evaluation revealed nanomolar AT1 receptor binding affinity and good AT1 receptor selectivity over AT2 receptor for all compounds of the series, a potent antagonistic activity in isolated rabbit aortic strip functional assay for compounds 6b, 6d and 6i was also demonstrated. Furthermore, evaluation in spontaneous hypertensive rats and a preliminary toxicity evaluation showed that compound 6i is an orally active AT1 receptor antagonist with low toxicity.

Design, synthesis and biological activity of 6-substituted carbamoyl benzimidazoles as new nonpeptidic angiotensin II AT1 receptor antagonists

A series of 6-substituted carbamoyl benzimidazoles were designed and synthesised as new nonpeptidic angiotensin II AT1 receptor antagonists. The preliminary pharmacological evaluation revealed a nanomolar AT1 receptor binding affinity for all compounds in the series, and a potent antagonistic activity in an isolated rabbit aortic strip functional assay for compounds 6f, 6g, 6h and 6k was also demonstrated. Furthermore, evaluation in spontaneous hypertensive rats and a preliminary toxicity evaluation showed that compound 6g is an orally active AT1 receptor antagonist with low toxicity.