123926-85-2Relevant academic research and scientific papers
Prenylated Bisphosphonates as Anti-tuberculosis Agents
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, (2010/10/03)
The invention provides methods to treat a mycobacterium infection and methods to inhibit mycobacterial polyprenyl pyrophosphate synthesis with a compound of formula I. The invention also provides novel compounds of formula I as well as salts and prodrugs
Synthesis and biological evaluation of a series of aromatic bisphosphonates
Barney, Rocky J.,Wasko, Brian M.,Dudakovic, Amel,Hohl, Raymond J.,Wiemer, David F.
experimental part, p. 7212 - 7220 (2010/11/18)
Geminal bisphosphonates display varied biological activity depending on the nature of the substituents on the central carbon atom. For example, the nitrogenous bisphosphonates zoledronate and risedronate inhibit the enzyme farnesyl diphosphate synthase wh
