123930-29-0

Upstream product

• 122253-30-9 5-Bromomethyl-4-(4-chloro-phenyl)-2,6-dimethyl-pyrimidine 
• 122253-07-0 [4-(4-Chloro-phenyl)-2,6-dimethyl-pyrimidin-5-yl]-methanol 
• 122818-19-3 4-(4-Chloro-phenyl)-2,6-dimethyl-pyrimidine-5-carboxylic acid ethyl ester 
• 123837-52-5 4-(4-Chloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 104-88-1 4-chlorobenzaldehyde 
• 86030-96-8 (2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-carbaldehyde 
• 122818-20-6 [4-(4-Chloro-phenyl)-2,6-dimethyl-pyrimidin-5-ylmethyl]-triphenyl-phosphonium; bromide 

Downstream Products

• 122254-18-6 (4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(E)-2-[4-(4-chloro-phenyl)-2,6-dimethyl-pyrimidin-5-yl]-vinyl}-tetrahydro-pyran-2-one 
• 122253-93-4 (4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(E)-2-[4-(4-chloro-phenyl)-2,6-dimethyl-pyrimidin-5-yl]-vinyl}-tetrahydro-pyran-2-ol 

Relevant academic research and scientific papers

Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 1. Lactones of Pyridine- and Pyrimidine-Substituted 3,5-Dihydroxy-6-heptenoic (-heptanoic) Acids

Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids 2-4 have been synthesized.Extensive exploration of structure-activity relationships led to several compounds exceeding the inhibitory activity of mevinolin (1b)