123931-04-4

Basic information

• Product Name: (R)-(+)-HA-966
• Synonyms: (R)-(+)-HA-966;R(+)-3-AMINO-1-HYDROXY-2-PYRROLIDINONE;(R)-(+)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE;R(+)-HA-966 R(+)-3-AMINO-1-HYDROX;Zinc03791818;(3R)-3-Amino-1-hydroxy-2-pyrrolidinone;(R)-3-amino-1-hydroxypyrrolidin-2-one 2,2,2-trifluoroacetate
• CAS NO: 123931-04-4
• Molecular Formula: C4H8N2O2
• Molecular Weight: 116.12
• Product Categories: Glutamate receptor
• Mol File: 123931-04-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 166℃
• Boiling Point: 258.6 °C at 760 mmHg
• Flash Point: 110.2 °C
• Appearance: white/solid
• Density: 1.436 g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: Desiccate at RT
• Solubility: H2O: soluble
• PKA: 7.19±0.20(Predicted)
• CAS DataBase Reference: (R)-(+)-HA-966(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-HA-966(123931-04-4)
• EPA Substance Registry System: (R)-(+)-HA-966(123931-04-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 123931-04-4(Hazardous Substances Data)

Usage

Uses

(R)-(+)-HA-966 is an antagonist/partial agonist at the glycine site of the NMDA receptor.

Biological Activity

Antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier. Also available as part of the NMDA Receptor - Glycine Site Tocriset? .

InChI:InChI=1/C4H8N2O2/c5-3-1-2-6(8)4(3)7/h3,8H,1-2,5H2/t3-/m1/s1

Upstream product

• 100-39-0 benzyl bromide 
• 123855-64-1 N-(tert-butoxycarbonyl)-D-methionine hydroxamic acid 
• 127977-31-5 (S)-2-Amino-N-((R)-1-hydroxy-2-oxo-pyrrolidin-3-yl)-3-phenyl-propionamide 
• 127977-32-6 (S)-2-Amino-N-((S)-1-hydroxy-2-oxo-pyrrolidin-3-yl)-3-phenyl-propionamide 
• 111772-93-1 ((S)-1-Hydroxy-2-oxo-pyrrolidin-3-yl)-carbamic acid benzyl ester 
• 1363373-26-5 C₁₂H₁₄N₂O₄ 

Downstream Products

• 123855-66-3 (S)-2-tert-Butoxycarbonylamino-3-phenyl-propionic acid (R)-3-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-oxo-pyrrolidin-1-yl ester 
• 2483-65-0 3-amino-pyrrolidin-2-one 

Relevant articles and documents

ETHYNYLBENZENE DERIVATIVES

Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.

Resolution and synthesis of the individual enantiomers of the glycine antagonist 3-amino-1-hydroxypyrrolidin-2-one (HA-966)

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