1239318-91-2Relevant academic research and scientific papers
Molecular analysis of carbohydrate-antibody interactions: Case study using a bacillus anthracis tetrasaccharide
Oberli, Matthias A.,Tamborrini, Marco,Tsai, Yu-Hsuan,Werz, Daniel B.,Horlacher, Tim,Adibekian, Alexander,Gauss, Dominik,Moeller, Heiko M.,Pluschke, Gerd,Seeberger, Peter H.
supporting information; experimental part, p. 10239 - 10241 (2010/09/06)
The process for selecting potent and effective carbohydrate antigens is not well-established. A combination of synthetic glycan microarray screening, surface plasmon resonance analysis, and saturation transfer difference NMR spectroscopy was used to dissect the antibody-binding surface of a carbohydrate antigen, revealing crucial binding elements with atomic-level detail. This analysis takes the first step toward uncovering the rules for structure-based design of carbohydrate antigens.
