1239346-97-4Relevant academic research and scientific papers
A stereoselective michael-mannich annelation strategy for the construction of novel tetrahydrocarbazoles
Williams, David R.,Bawel, Seth A.,Schaugaard, Richard N.
, p. 5098 - 5101 (2017)
A novel annelation strategy has been devised for stereoselective synthesis of tetrahydrocarbazoles. The pathway features a regio-and stereocontrolled condensation of indole and its substituted derivatives with electron-deficient 1, 3-dienes via a Michael-Mannich reaction sequence. An extension of this method to include crossconjugated allenes as substrates also results in a Michael-Mannich-Michael cascade, incorporating 2 equiv of indole with increasing product complexity. The formal 4π + 2π cyclization describes a concise route to polycyclic alkaloids of this family.
Regioselective formation of 1,1-disubstituted allenylsilanes via cross-coupling reactions of 3-tri-n-butylstannyl-1-trimethylsilyl-1-propyne
Williams, David R.,Shah, Akshay A.
supporting information; experimental part, p. 4297 - 4299 (2010/08/19)
The regioselective Stille cross-coupling reactions of 3-tri-n-butylstannyl- 1-trimethylsilyl-1-propyne demonstrate isomerization following the initial transmetalation step resulting in allenyl palladium intermediates for reductive coupling to yield conjug
