1239358-85-0

Usage

Uses

Used in Pharmaceutical Industry:
NS-018 (hydrochloride) is used as a potential candidate for the treatment of hematological malignancies, such as myeloproliferative neoplasms (MPN) and acute myeloid leukemia (AML), for its ability to selectively inhibit the activity of JAK2 and disrupt the signaling pathways that drive the growth and survival of cancer cells.
Used in Drug Development:
NS-018 (hydrochloride) is used as a research tool in preclinical studies for its promising results in inhibiting the growth of cancer cells and reducing tumor burden in animal models, providing insights into its potential therapeutic applications and efficacy in treating blood cancers.

Upstream product

• 1239358-86-1 N₂-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N₆-(pyrazin-2-yl)pyridine-2,6-diamine 
• 1239362-91-4 (S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine 
• 98027-84-0 2,6-dichloro-4-iodopyridine 
• 1239362-90-3 2,6-dichloro-4-(1-methyl-1H-pyrazol-4-yl)pyridine 

Relevant academic research and scientific papers

Therapeutic agent pcnsl (by machine translation)

The present invention provides a malignant lymphoma therapeutic or preventive agent that comprises as the active ingredient a compound represented by general formula [1] as defined by (I) or (II), or a pharmaceutically acceptable salt thereof. [1] (I) X is CH or N; R1 is a halogen; R2 is a halogen, H, a cyano, a group represented by general formula [9], [9] an optionally substituted heteroaryl, or the like; R3 is H or a hydroxyl; R4 is H or an alkyl; and R5 is H or an alkyl. (II) X is -CRA, RA is -CORB, RB is an optionally substituted amino, alkoxy, or saturated cyclic amino group; R1 is a halogen; R2 is H; R3is H or a hydroxy; R4 is H or an alkyl; and R5 is H or an alkyl.

AMINOPYRAZINE DERIVATIVE AND MEDICINE

The present invention relates to a compound represented by general formula [1] satisfying the following (I) or (II), or a pharmaceutical acceptable salt of the compound. (I) X is CH or N; R1 is a halogen atom,; and R2 is H, a halogen atom, CN, [2], [3], [8], [9], an —O-alkyl, an —O-(saturated ring), etc. [2]: —C(RC)(RD)(RE) (RC to RE each are H, an alkyl, etc.) [3]: —N(RF)(RG) (RF and RG each are H, OH, amino, a (hetero)aryl, etc.) [8]: —C(═O)RL (RL is an alkyl, OH, an alkoxy, amino, etc.) [9]: a (substituted)phenyl; (II) X is >C—C(—O)R3 (R3 is a (substituted)amino, an alkoxy, OH, etc.); R1 is a halogen atom; R2 is H; R3 is H or OH; and R3 and R4 each are H or an alkyl.