123941-02-6

Basic information

• Product Name: 4-({2-[(2,6-dimethylphenyl)amino]-2-oxoethyl}amino)butanoic acid
• Synonyms: butanoic acid, 4-[[2-[(2,6-dimethylphenyl)amino]-2-oxoethyl]amino]-
• CAS NO: 123941-02-6
• Molecular Formula: C₁₄H₂₀N₂O₃
• Molecular Weight: 264.3202
• Mol File: 123941-02-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 477.2°C at 760 mmHg
• Flash Point: 242.4°C
• Density: 1.177g/cm³
• Vapor Pressure: 6.48E-10mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: 4-({2-[(2,6-dimethylphenyl)amino]-2-oxoethyl}amino)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-({2-[(2,6-dimethylphenyl)amino]-2-oxoethyl}amino)butanoic acid(123941-02-6)
• EPA Substance Registry System: 4-({2-[(2,6-dimethylphenyl)amino]-2-oxoethyl}amino)butanoic acid(123941-02-6)

Safety Data

• Hazardous Substances Data: 123941-02-6(Hazardous Substances Data)

Upstream product

• 87-62-7 2,6-dimethylaniline 
• 1131-01-7 2-chloro-N-(2,6-dimethylphenyl)acetamide 
• 56-12-2 4-amino-n-butyric acid 

Relevant articles and documents

Synthesis and anticonvulsant activity of 4-(2-(2,6-dimethylphenylamino)-2-oxoethylamino)-N-(substituted)butanamides: A pharmacophoric hybrid approach

A series of pharmacophoric hybrids of ameltolide-γ-aminobutyric acid (GABA)-amides was designed, synthesized, and evaluated for their anticonvulsant and neurotoxic properties. Initial anticonvulsant screening was performed using intraperitoneal (ip) maximal electroshock-induced seizure (MES), subcutaneous pentylenetetrazole (scPTZ), and subcutaneous picrotoxin (scPIC)-induced seizure threshold tests. All the compounds had improved lipophilicity and the pharmacological activity profile confirmed their blood-brain barrier penetration. The titled compounds showed promising activity in scPIC screen indicating the involvement of GABA-mediation. Compound 4-(2-(2,6-dimethylaminophenylamino)-2-oxoethylamino)-N-(2,6-dimethylphenyl) butanamide (7) emerged as the most potent derivative effective in all the three animal models of seizure with no neurotoxicity at the anticonvulsant dose.