123942-11-0

Basic information

• Product Name: 4'-BroMo-2',5'-difluoroacetophenone, 96%
• Synonyms: 4'-BroMo-2',5'-difluoroacetophenone, 96%;1-(4-Bromo-2,5-difluorophenyl)ethanone
• CAS NO: 123942-11-0
• Molecular Formula: C₈H₅BrF₂O
• Molecular Weight: 235.0255064
• Mol File: 123942-11-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4'-BroMo-2',5'-difluoroacetophenone, 96%(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-BroMo-2',5'-difluoroacetophenone, 96%(123942-11-0)
• EPA Substance Registry System: 4'-BroMo-2',5'-difluoroacetophenone, 96%(123942-11-0)

Safety Data

• Hazardous Substances Data: 123942-11-0(Hazardous Substances Data)

Upstream product

• 28314-82-1 4-bromo-2,5-difluorobenzoic acid 
• 75-16-1 methylmagnesium bromide 
• 127-19-5 N,N-dimethyl acetamide 
• 327-51-5 1,4-dibromo-2,5-difluorobenzene 
• 399-94-0 2-bromo-1,4-difluorobenzene 
• 75-36-5 acetyl chloride 

Downstream Products

• 1437800-95-7 benzyl 2-aminoethyl(1-(4-bromo-2,5-difluorophenyl)ethyl)carbamate 2,2,2-trifluoroacetate 
• 1437800-96-8 tert-butyl 4-(2-((benzyloxycarbonyl)(1-(4-bromo-2,5-difluorophenyl)ethyl)amino)ethylamino)piperidine-1-carboxylate 
• 1437800-97-9 tert-butyl 4-(2-((benzyloxycarbonyl)(1-(2,5-difluoro-4-(methylsulfonyl)phenyl)ethyl)amino)ethylamino)piperidine-1-carboxylate 
• 1437800-92-4 tert-butyl 4-(3-(1-(2,5-difluoro-4-(methylsulfonyl)phenyl)ethyl)-2-oxoimidazolidin-1-yl)piperidine-1-carboxylate 
• 1437800-93-5 benzyl (1-(4-bromo-2,5-difluorophenyl)ethyl)(2-((tert-butoxycarbonyl)amino)ethyl)carbamate 
• 1315179-69-1 1-(2-aminobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline 
• 1315180-08-5 1-(2-aminobenzyl)-7-bromo-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline 
• 1315180-06-3 (E)-1-(4-bromo-2, 5-difluorophenyl)-3-dimethylamino-2-buten-1-one 
• 1394120-64-9 6-bromo-5-fluoro-3-methyl-1H-indazole 
• 1394120-63-8 (E)-[1-(4-bromo-2,5-difluorophenyl)ethylidene]hydrazine 
• 167556-68-5 7-(2,6-Dimethyl-pyridin-4-yl)-6-fluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 167556-65-2 ethyl 7-bromo-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate 
• 167556-70-9 (Z)-2-(4-Bromo-2,5-difluoro-benzoyl)-3-tert-butylamino-acrylic acid ethyl ester 
• 123942-14-3 (Z)-2-(4-Bromo-2,5-difluoro-benzoyl)-3-cyclopropylamino-acrylic acid ethyl ester 

Relevant articles and documents

TRIAZOLYL PYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS

The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR

The invention relates to novel compounds of Formula I: wherein A, Y, R1, R2 and the subscript b each has the meaning as described herein and compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates, metabolites, isotopes, pharmaceutically acceptable salts, or prodrugs thereof. Compounds of Formula I and pharmaceutical compositions thereof are useful in the treatment of disease and disorders in which undesired or over-activation of NF-kB signaling is observed.