1239440-07-3Relevant articles and documents
Synthesis and characterization of novel phenylindoles as potential probes for imaging of β-amyloid plaques in the brain
Watanabe, Hiroyuki,Ono, Masahiro,Haratake, Mamoru,Kobashi, Nobuya,Saji, Hideo,Nakayama, Morio
experimental part, p. 4740 - 4746 (2010/08/19)
We synthesized a novel series of phenylindole (PI) derivatives and evaluated their biological activities as probes for imaging Aβ plaques in vivo. The affinity for Aβ plaques was assessed by an in vitro-binding assay using pre-formed synthetic Aβ aggregates. 2-Phenyl-1H-indole (2-PI) derivatives showed high affinity for Aβ42 aggregates with Ki values ranging from 4 to 32 nM. 2-PI derivatives clearly stained Aβ plaques in an animal model of AD. In biodistribution experiments using normal mice, 2-PI derivatives displayed sufficient uptake for imaging, ranging from 1.1% to 2.6% ID/g. Although additional modifications are necessary to improve uptake by and clearance from the brain, 2-PI derivatives may be useful as a backbone structure to develop novel Aβ imaging agents.
