1239465-62-3Relevant academic research and scientific papers
Tandem mass spectrometry based investigation of cinnamylideneacetophenone derivatives: Valuable tool for the differentiation of positional isomers
Resende, Diana I. S. P.,Silva, Eduarda M. P.,Barros, Cristina,Domingues, M. Rosario M.,Silva, Artur M. S.,Cavaleiro, Jose A. S.
experimental part, p. 3185 - 3195 (2012/04/10)
Cinnamylideneacetophenones have been extensively used as versatile starting materials in numerous different transformations. The structural characterization of this type of compounds is, therefore, of crucial importance since it can give information on th
Highly enantioselective 1, 4-michael additions of nucleophiles to unsaturated aryl ketones with organocatalysis by bifunctional cinchona alkaloids
Oliva, Cristina G.,Silva, Artur M. S.,Resende, Diana I. S. P.,Paz, Filipe A. A.,Cavaleiro, Jose A. S.
experimental part, p. 3449 - 3458 (2010/09/07)
The development of general and efficient asymmetric organocatalytic additions of malononitrile and nitromethane to 1, 5-diarylpenta-2, 4-dien-1-ones (cinnamylideneacetophenones) catalyzed by cinchona organocatalysts is reported. The reactions afforded excellent enantioselectivities (up to 99%), high yields (up to 97%), and exclusive 1, 4-addition regioselectivities. The potential of these new enantioselective additions lies in the demonstration that organocatalysts bearing primary amino groups in combination with TFA provide effective catalytic systems for the activation of a broad range of aryl ketones under mild conditions to give compounds with high levels of enantioselectivity and yields.
