1239477-46-3Relevant academic research and scientific papers
Diastereoselective synthesis of propargylic fluorides and its application in preparation of monofluorinated sugar
Fan, Shilu,He, Chun-Yang,Zhang, Xingang
, p. 5218 - 5228 (2010)
An effective method to diastereoselectively synthesize enantioenriched propargylic fluorides was developed via SNI type reaction of DAST participated dehydroxy-fluorination of diastereomeric propargylic alcohol cobaltcarbonyl complexes. A serious of propargylic fluorides can be prepared by this approach in good yields with moderate to high diastereoselectivities. To demonstrate the application of this approach in synthesis, monofluorinated sugar 12, an important and versatile building block, was prepared in an efficient manner.
