1239481-15-2

Upstream product

• 626-55-1 3-Bromopyridine 
• 1239481-06-1 4-phenyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-1H-1,2,3-triazole 
• 107047-10-9 p-bromobenzylazide 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 1692-25-7 3-pyridylboronic acid 
• 126800-09-7 1-(4-bromobenzyl)-4-phenyl-1H-1,2,3-triazole 

Relevant academic research and scientific papers

Discovery of novel anti-angiogenesis agents. Part 10: Multi-target inhibitors of VEGFR-2, Tie-2 and EphB4 incorporated with 1,2,3-triazol

VEGFR-2, Tie-2, and EphB4 are essential for both angiogenesis and tumorigenesis. Herein, we developed a series of pyridines incorporated with 1,2,3-triazole as multi-target inhibitors based on the crystal structure alignment of the kinase domain of angiog

Pyridine compound and application

The invention provides a pyridine compound and application. Based on the find of VEGFR-2 (Vascular Endothelial Growth Factor Receptor-2), EphB4 (Ephrin type-B receptor 4) and TIE-2 compensatory activation, biphenyl arylurea is used as a novel leading comp

A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions

The stable benzylazido-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide-alkyne cycloaddition and Suzuki coupling reactions.