1239481-44-7Relevant academic research and scientific papers
Protein synthesis assisted by native chemical ligation at leucine
Harpaz, Ziv,Siman, Peter,Ajish Kumar,Brik, Ashraf
, p. 1232-1235+1158 (2010)
(Chemical Equation Presented) Triggering leucine: A new ligation strategy of using β-mercaptoleucine coupled with desulfurization at leucine sites was developed, and its applicability in protein synthesis is presented. The efficiency of our Leu-NCL was examined in several model peptides and utilized for the first total synthesis of HIV-1 Tat protein.
