1239492-98-8

Basic information

• Product Name: C₂₂H₂₁NO₆
• Synonyms: C₂₂H₂₁NO₆
• CAS NO: 1239492-98-8
• Molecular Weight: 395.412
• Mol File: 1239492-98-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₁NO₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₁NO₆(1239492-98-8)
• EPA Substance Registry System: C₂₂H₂₁NO₆(1239492-98-8)

Safety Data

• Hazardous Substances Data: 1239492-98-8(Hazardous Substances Data)

Upstream product

• 1080-06-4 L-Tyr-OMe 
• 700359-91-7 piperic acid mesylate 

Downstream Products

• 1239493-07-2 C₂₁H₁₉NO₆ 
• 1239493-17-4 C₂₂H₂₅NO₆ 

Relevant articles and documents

Synthesis and Antileishmanial activity of Piperoyl-Amino Acid Conjugates

Based on reported antileishmanial activity of naturally occurring alkaloid piperine and amino acid esters,their conjugates were synthesized by the hydrolysis of piperine to piperic acid followed by reaction with amino acid methyl esters. These conjugates were further converted to compounds with free carboxyl group and those with reduced double bonds. The synthesized compounds were evaluated for activity against promastigote and amastigote forms of L. donovani in vitro. All the compounds showed better activity than either piperine or the amino acid methyl esters. Piperoyl-valine methyl ester was the most active compound showing an IC50 of 0.075 mM against the amastigotes. Two active compounds were evaluated for in vivo activity in golden hamster model of leishmaniasis.