1239573-77-3

Upstream product

• 57056-93-6 N-methyl-2-iodoaniline 
• 563-76-8 α-bromopropionyl bromide 

Downstream Products

• 1029963-81-2 2-azido-N-(2-iodophenyl)-N-methylpropanamide 
• 1390630-91-7 (E)-N-(2-iodophenyl)-3-(4-methoxyphenyl)-N,2-dimethylacrylamide 
• 1390630-92-8 (E)-N-(2-iodophenyl)-N,2-dimethyl-3-(4-(trifluoromethyl)phenyl)acrylamide 
• 1390630-93-9 (E)-3-(4-bromophenyl)-N-(2-iodophenyl)-N,2-dimethylacrylamide 
• 1390630-96-2 (E)-tert-butyl 3-(3-((2-iodophenyl)(methyl)amino)-2-methyl-3-oxoprop-1-en-1-yl)-1H-indole-1-carboxylate 
• 1390631-08-9 diethyl (1-((2-iodophenyl)(methyl)amino)-1-oxopropan-2-yl)phosphonate 

Relevant academic research and scientific papers

Domino carbopalladation-cross-coupling for the synthesis of 3,3-disubstituted oxindoles

This study examines a domino carbopalladation-cross-coupling reaction for the formation of valuable oxindole scaffolds. Furthermore, the reaction sequence forges vicinal stereocenters in a stereospecific manner through the formation of two carbon-carbon bonds and, thereby, rapidly generates complexity. The reaction gives high yields for a variety of acrylamide substrates, and various organoboranes have also been evaluated for the cross-coupling. This work offers insight into the relative rates determining a successful carbopalladation-cross- coupling reaction and how to favor the desired reaction pathway.

Iminyl radicals from α-azido o-iodoanilides via 1,5-H transfer reactions of aryl radicals: New transformation of α-azido acids to decarboxylated nitriles

(Chemical Equation Presented) The radical reaction of tributyltin hydride with o-iodo-N-methylanilides derived from α-azido acids provides an excellent access to α-(aminocarbonyl)iminyl radicals through 1,5-hydrogen transfer reaction of initially formed aryl radicals followed by β-elimination of dinitrogen from ensuing α-azido-α- (aminocarbonyl)alkyl radicals. The outcoming iminyls display a peculiar tendency to form corresponding nitriles by β-elimination of aminocarbonyl radicals.