1239575-73-5Relevant academic research and scientific papers
Design, synthesis and antibacterial activity of novel andrographolide derivatives
Wang, Zhongli,Yu, Pei,Zhang, Gaoxiao,Xu, Lipeng,Wang, Dingyuan,Wang, Liang,Zeng, Xiangping,Wang, Yuqiang
experimental part, p. 4269 - 4274 (2010/09/12)
A series of andrographolide derivatives were synthesized through a facile condensation reaction with different carboxylic acids. The new compounds were characterized and screened for their antibacterial activities. A number of the new compounds significantly reduced bacterial quorum sensing virulence factors production in Pseudomonas aeruginosa, essential for pathogenesis. Compound 11b showed the best activity among all the new compounds.
