1239579-87-3Relevant academic research and scientific papers
Synthesis and biological activity of 2-hydroxynicotinoyl-serine-butyl esters related to antibiotic UK-3A
Arsianti, Ade,Hanafi, Muhammad,Saepudin, Endang,Morimoto, Tsumoru,Kakiuchi, Kiyomi
, p. 4018 - 4020 (2010)
Novel 2-hydroxynicotinoyl-serine-butyl esters have been synthesized. Three-step reactions from l-serine by esterification with n-butanol, amidation with 2-hydroxynicotinic acid and esterification with the corresponding carboxylic acids gave AD-1, AD-2 and AD-3. The toxicity level of esters were determined by Brine shrimp assay, and antibiotic activity was tested against Escherichia coli, Bacillus subtilis, Staphylococcus aureus and Candida albicans. AD-3 showed greater activity as a growth inhibitor of B. subtilis and S. aureus compared to Antimycin A3.
