1239583-15-3Relevant academic research and scientific papers
Synthesis of nucleotidylated poliovirus VPg proteins
Van Der Heden Van Noort, Gerbrand J.,Overkleeft, Herman S.,Van Der Marel, Gijsbert A.,Filippov, Dmitri V.
, p. 5733 - 5736 (2010)
Phosphitylation of the side chain hydroxyl function of Fmoc protected tyrosine with 5′-phosphoramidites of suitably protected cytidine, adenosine, and guanosine, followed by oxidation gave three novel nucleotidylated amino acid building blocks. After protective group manipulation, these building blocks were used in a solid phase peptide synthesis to afford the nucleotidylated poliovirus proteins VPgpC, VPgpA, and VPgpG.
