1239588-44-3Relevant academic research and scientific papers
Enantioselective 6-endo-trig Wacker-type cyclization of 2-geranylphenols: Application to a facile synthesis of (-)-cordiachromene
Takenaka, Kazuhiro,Tanigaki, Yugo,Patil, Mahesh L.,Rao, C. V. Laxman,Takizawa, Shinobu,Suzuki, Takeyuki,Sasai, Hiroaki
experimental part, p. 767 - 770 (2010/11/04)
An enantioselective intramolecular oxidative cyclization of 2-geranylphenols catalyzed by a Pd(II)-spiro bis(isoxazoline) complex is reported. The reaction proceeds in a 6-endo-trig manner to give chromene derivatives in reasonable yields and with moderate enantioselectivities. This transformation can be applied to a protecting-group-free total synthesis of naturally occurring cordiachromene.
