1239592-55-2Relevant academic research and scientific papers
Alchivemycin A, a bioactive polycyclic polyketide with an unprecedented skeleton from streptomyces sp.
Igarashi, Yasuhiro,Kim, Youngju,In, Yasuko,Ishida, Toshimasa,Kan, Yukiko,Fujita, Tsuyoshi,Iwashita, Takashi,Tabata, Hirokazu,Onaka, Hiroyasu,Furumai, Tamotsu
, p. 3402 - 3405 (2010)
(Equation Presented). Alchivemycin A, a novel polycyclic polyketide, was isolated from the culture extract of a plant-derived actinomycete Streptomyces sp. The structure and relative configuration were elucidated by spectroscopic analysis and X-ray crystallography, and the absolute configuration was determined by a 1H NMR anisotropy method using MPA ester derivatization. The new compound contains an unprecedented heterocyclic ring system, 2H-tetrahydro-4,6-dioxo-1,2-oxazine. Alchivemycin A showed potent antimicrobial activity against Micrococcus luteus and inhibitory effects on tumor cell invasion.
