1239604-26-2Relevant academic research and scientific papers
Investigations on the 4-Quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands
Pasquini, Serena,Ligresti, Alessia,Mugnaini, Claudia,Semeraro, Teresa,Cicione, Lavinia,De Rosa, Maria,Guida, Francesca,Luongo, Livio,De Chiaro, Maria,Cascio, Maria Grazia,Bolognini, Daniele,Marini, Pietro,Pertwee, Roger,Maione, Sabatino,Di Marzo, Vincenzo,Corelli, Federico
supporting information; experimental part, p. 5915 - 5928 (2010/11/16)
A set of quinolone-3-carboxamides 2 bearing diverse substituents at position 1, 3, and 6 of the bicyclic nucleus was prepared. Except for six compounds exhibiting Ki > 100 nM, all the quinolone-3-carboxamides 2 proved to be high affinity CB2 li
