1239610-22-0Relevant academic research and scientific papers
Catalytic anti-selective asymmetric Henry (nitroaldol) reaction catalyzed by Cu(I)-amine-imine complexes
Qiong Ji, Yao,Qi, Gao,Judeh, Zaher M.A.
, p. 2065 - 2070 (2011)
Chiral complex derived from N-methyl-C1-tetrahydro-1,1′- bisisoquinolines (R)-1b and Cu(I)Cl promoted the diastereoselective Henry reaction of nitroethane with a series of aromatic and aliphatic aldehydes. The nitroalcohol adducts were obtained in excellent yields (up to 95%), moderate anti-selectivity (up to 2.6:1), and good enantioselectivity (up to 92% ee) without any special precautions to exclude moisture or air.
A highly syn-selective nitroaldol reaction catalyzed by Cu II-bisimidazoline
Cheng, Liang,Dong, Jiaxing,You, Jingsong,Gao, Ge,Lan, Jingbo
supporting information; experimental part, p. 6761 - 6765 (2010/08/06)
(Chemical Equation Presented) Catalyzing Henry: Chiral bisimidazoline 1-Cu(OTf)2, in the presence of N-methylmorpholine as a base, was discovered to efficiently catalyze the nitroaldol reaction in a highly syn- and enantioselective manner for a broad range of aldehydes, including aromatic, heteroaromatic, α,β-unsaturated, and aliphatic aldehydes (see scheme).
