1239669-28-3Relevant academic research and scientific papers
ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors
Xu, Baihua,Feng, Yan,Lv, Binhua,Xu, Ge,Zhang, Lili,Du, Jiyan,Peng, Kun,Xu, Min,Dong, Jiajia,Zhang, Wenbin,Zhang, Ting,Zhu, Liangcheng,Ding, Haifeng,Sheng, Zelin,Welihinda, Ajith,Seed, Brian,Chen, Yuanwei
experimental part, p. 4422 - 4432 (2010/09/12)
A series of 2-substituted C-aryl glucosides have been synthesized and evaluated for inhibition of hSGLT1 and hSGLT2. Introduction of an appropriate ortho substituent at the proximal phenyl ring adjacent to the glycosidic bond was found to improve SGLT2 in
Conformationally constrained spiro C-arylglucosides as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors
Lv, Binhua,Feng, Yan,Dong, Jiajia,Xu, Min,Xu, Baihua,Zhang, Wenbin,Sheng, Zelin,Welihinda, Ajith,Seed, Brian,Chen, Yuanwei
scheme or table, p. 827 - 831 (2011/02/22)
(Chemical Equation Presented) Sodium glucose co-transporter 2 (SGLT2) is an emerging target for the treatment of type 2 diabetes mellitus (DM2). Here, the synthesis and preliminary biological evaluation of a series of potent, selective SGLT2 inhibitors, derived from a rigid spiro C-arylglucoside scaffold, is described.
