1239670-64-4

Basic information

• Product Name: tert-butyl ((3S,6S,9S,10aR)-9-azido-3-benzhydrylcarbamoyl-5-oxodecahydropyrrolo[1,2-a]azocin-6-yl)carbamate
• Synonyms: tert-butyl ((3S,6S,9S,10aR)-9-azido-3-benzhydrylcarbamoyl-5-oxodecahydropyrrolo[1,2-a]azocin-6-yl)carbamate
• CAS NO: 1239670-64-4
• Molecular Weight: 532.643
• Mol File: 1239670-64-4.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl ((3S,6S,9S,10aR)-9-azido-3-benzhydrylcarbamoyl-5-oxodecahydropyrrolo[1,2-a]azocin-6-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl ((3S,6S,9S,10aR)-9-azido-3-benzhydrylcarbamoyl-5-oxodecahydropyrrolo[1,2-a]azocin-6-yl)carbamate(1239670-64-4)
• EPA Substance Registry System: tert-butyl ((3S,6S,9S,10aR)-9-azido-3-benzhydrylcarbamoyl-5-oxodecahydropyrrolo[1,2-a]azocin-6-yl)carbamate(1239670-64-4)

Safety Data

• Hazardous Substances Data: 1239670-64-4(Hazardous Substances Data)

Upstream product

• 1239670-60-0 C₂₉H₃₇N₃O₅ 

Relevant articles and documents

Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins

A series of compounds were designed and synthesized as antagonists of cIAP-1/2 and XIAP based upon our previously identified lead compound SM-122 (1). The most potent of these (7) binds to XIAP, cIAP-1, and cIAP-2 proteins with Ki values of 36, a cell-free caspase-9 functional assay, efficiently induces cIAP-1 degradation in cells at concentrations as low as 10 nM, and triggers activation of caspases and PARP cleavage in the MDA-MB-231 breast cancer cell line. Compound 7 potently inhibits cell growth in the MDA-MB-231 cancer cell line with an IC50 value of 200 nM and is 9 times more potent than compound 1.