1239701-22-4Relevant academic research and scientific papers
Design and synthesis of functionalized trisaccharides as p53-peptide mimics
Sakurai, Kaori,Kahne, Daniel
scheme or table, p. 3724 - 3727 (2010/08/22)
Oligosaccharides represent potentially useful scaffolds for the development of peptidomimetics. We report here the design and synthesis of functionalized trisaccharides modeled after an α-helical 15-mer peptide region of p53 which binds to its cellular regulator MDM2. The trisaccharide scaffold was obtained efficiently by applying the sulfoxide glycosylation reaction as a key methodology.
