1239709-99-9Relevant academic research and scientific papers
Asymmetric synthesis of allylic secondary alcohols: Anewgeneral approach for the preparation of α-amino acids
Drummond, Lorna J.,Sutherland, Andrew
experimental part, p. 5349 - 5356 (2010/08/06)
A new general approach for the synthesis of optically active a-amino acids has been developed.The key steps involve a ruthenium catalysed cross-coupling reaction to give a range of α,β-unsaturated ketones, which were then reduced to allylic secondary alcohols in the presence of a chiral CBS oxazaborolidine.A thermal Overman rearrangement was used to prepare a series of allylic trichloroacetimidates and these were converted under standard conditions to the target α-amino acids in good overall yields.
