1239744-46-7Relevant academic research and scientific papers
Highly enantioselective addition of arylzinc reagents to aldehydes promoted by chiral aziridine alcohols
Wujkowska, Zuzanna,Jarzyński, Szymon,Pieczonka, Adam M.,Le?niak, Stanis?aw,Rachwalski, Micha?
, p. 1238 - 1244 (2016)
Enantiomerically pure, chiral secondary and tertiary aziridine alcohols have proven to be highly efficient catalysts for enantioselective asymmetric additions of arylzinc species to aldehydes leading to products in high chemical yields (up to 90%) and with ee's up to 90%. The influence of the stereogenic centers located at the aziridine subunit on the stereochemical course of the reaction is discussed.
Aryl bromides as inexpensive starting materials in the catalytic enantioselective arylation of aryl aldehydes: The additive TMEDA enhances the enantioselectivity
Yang, Yong-Xin,Liu, Yue,Zhang, Lei,Jia, Yan-E,Wang, Pei,Zhuo, Fang-Fang,An, Xian-Tao,Da, Chao-Shan
, p. 10696 - 10702 (2015/02/19)
We used aryl bromides as inexpensive starting materials to enantioselectively arylate aldehydes in one pot. Aryl bromides readily transfer aryls to aryllithiums with n-butyllithium, successively to triarylaluminums with aluminum chloride, and then to aryltitaniums with titanium isopropoxide. Finally aryltitaniums arylate aldehydes catalyzed by (S)-H8-BINOL-Ti(Oi-Pr)2 in excellent yields and enantioselectivities. The additive TMEDA evidently suppresses the racemic background reaction promoted by LiCl generated from salt metathesis. This procedure represents a cost-effective and operationally convenient method for enantioenriched diarylmethanols.
Copper-dipyridylphosphine-catalyzed hydrosilylation: Enantioselective synthesis of aryl- and heteroaryl cycloalkyl alcohols
Qi, Shan-Bin,Li, Min,Li, Shijun,Zhou, Ji-Ning,Wu, Jun-Wen,Yu, Feng,Zhang, Xi-Chang,Chan, Albert S.C.,Wu, Jing
, p. 929 - 937 (2013/02/26)
The non-precious metal copper-catalyzed enantioselective hydrosilylation of a vast array of aryl cycloalkyl ketones with different ring sizes was studied systematically for the first time (up to 99% enantiomeric excess). The results demonstrated that the
Catalytic enantioselective synthesis of sterically demanding alcohols using di(2°-alkyl)zinc prepared by the refined Charette's method
Hatano, Manabu,Mizuno, Tomokazu,Ishihara, Kazuaki
supporting information; experimental part, p. 5443 - 5445 (2010/10/04)
A highly practical, catalytic enantioselective 2°-alkyl addition to aldehydes and ketones was developed. Chiral phosphoramide ligand (1) with salt-free and solvent-free di(2°-alkyl)zinc reagents prepared from (2°-alkyl)MgCl was essential. The Royal Society of Chemistry 2010.
