1239750-79-8

Basic information

• Product Name: (E)-2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl 3-(4-(benzyloxy)phenyl)acrylate
• CAS NO: 1239750-79-8
• Molecular Weight: 407.426
• Mol File: 1239750-79-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl 3-(4-(benzyloxy)phenyl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl 3-(4-(benzyloxy)phenyl)acrylate(1239750-79-8)
• EPA Substance Registry System: (E)-2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl 3-(4-(benzyloxy)phenyl)acrylate(1239750-79-8)

Safety Data

• Hazardous Substances Data: 1239750-79-8(Hazardous Substances Data)

Upstream product

• 6272-45-3 (E)-4-benzyloxycinnamic acid 
• 30746-54-4 2-(5-nitro-2-methyl-1-imidazolyl)ethyl methanesulfonate 

Relevant articles and documents

Synthesis, molecular modeling, and biological evaluation of cinnamic acid metronidazole ester derivatives as novel anticancer agents

A series of novel cinnamic acid metronidazole ester derivatives have been designed and synthesized, and their biological activities were also evaluated as potential EGFR and HER-2 kinase inhibitors. Compound 3h showed the most potent biological activity (IC50 = 0.62 μM for EGFR and IC50 = 2.15 μM for HER-2). Docking simulation was performed to position compound 3h into the EGFR active site to determine the probable binding model. Antiproliferative assay results demonstrated that some of these compounds possessed good antiproliferative activity against MCF-7. Compound 3h with potent inhibitory activity in tumor growth inhibition may be a potential anticancer agent.