1239766-75-6Relevant academic research and scientific papers
Synthesis and cytotoxic evaluation of disubstituted N-acylhydrazones pyrazinecarbohydrazide derivatives
De Ferreira, Marcelle L.,Candea, Andre L. P.,Henriques, Maria Das Gracas M. De O.,Kaiser, Carlos R.,Lima, Camilo H. Da S.,De Souza, Marcus V. N.
, p. 275 - 280 (2011/03/18)
A series of seventeen disubstituted N-acylhydrazone pyrazinecarbohydrazide (4-20) have been synthesized and evaluated for their cell viabilities, were compared to another monosubstituted derivatives previously synthesized by us. This study indicated that the position and nature of the substituents in the aromatic ring influence the cytotoxicity of this series.
Synthesis and pharmacological evaluation of pyrazine N-acylhydrazone derivatives designed as novel analgesic and anti-inflammatory drug candidates
Silva, Yolanda Karla Cupertino Da,Augusto, Cristina Villarinho,Barbosa, Maria Leticia De Castro,Melo, Gabriela Muniz De Albuquerque,Queiroz, Aline Cavalcanti De,Dias, Thays De Lima Matos Freire,Junior, Walfrido Bispo,Barreiro, Eliezer J.,Lima, Lidia Moreira,Alexandre-Moreira, Magna Suzana
experimental part, p. 5007 - 5015 (2010/09/05)
In this paper, we report the synthesis and pharmacological evaluation of pyrazine N-acylhydrazone (NAH) derivatives (2a-s) designed as novel analgesic and anti-inflammatory drug candidates. This series was planned by molecular simplification of prototype
