1239766-85-8

Upstream product

• 16184-89-7 4'-bromo-2,2,2-trifluoroacetophenone 
• 1774-47-6 trimethylsulfoxonium iodide 

Downstream Products

• 1239767-01-1 (R)-3-azido-2-(4-bromophenyl)-1,1,1-trifluoropropan-2-ol 
• 1589535-24-9 2-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1-trifluoro-4-hexyn-2-ol 
• 1589535-23-8 2-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1-trifluoro-4-pentyn-2-ol 
• 1589535-22-7 2-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1-trifluoro-3-methoxy-2-propanol 
• 1589535-21-6 3-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-4,4,4-trifluoro-3-hydroxybutanenitrile 
• 1450620-78-6 2-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol 
• 1589535-17-0 C₁₆H₁₉F₃N₂O₂ 
• 1572928-04-1 tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2-(trifluoromethyl)-2-oxiranyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate 
• 1572928-03-0 tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate 
• 1450620-98-0 (2S)-1-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-2-(1-propyn-1-yl)piperazine 
• 1450620-77-5 benzyl (3S)-4-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate 
• 1450620-70-8 4-(4-bromophenyl)-2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolane 
• 1361218-24-7 2-(4-bromophenyl)-3,3,3-trifluoro-1,2-propanediol 
• 1572927-97-9 (3R)-3-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-4,4,4-trifluoro-3-hydroxybutanenitrile 

Relevant academic research and scientific papers

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N′-arylpiperazine series

We have recently reported a novel approach to increase cytosolic glucokinase (GK) levels through the binding of a small molecule to its endogenous inhibitor, glucokinase regulatory protein (GKRP) these initial investigations culminated in the identification of 2-(4-((2S)-4-((6-amino-3- pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3, 3-hexafluoro-2-propanol (1, AMG-3969), a compound that effectively enhanced GK translocation and reduced blood glucose levels in diabetic animals. Herein we report the results of our expanded SAR investigations that focused on modifications to the aryl carbinol group of this series. Guided by the X-ray cocrystal structure of compound 1 bound to hGKRP, we identified several potent GK-GKRP disruptors bearing a diverse set of functionalities in the aryl carbinol region. Among them, sulfoximine and pyridinyl derivatives 24 and 29 possessed excellent potency as well as favorable PK properties. When dosed orally in db/db mice, both compounds significantly lowered fed blood glucose levels (up to 58%).

TRICYCLIC ALKYNES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN

The present invention relates to tricyclic alkyne compounds of formula I that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where gluco

Resolution of 2,2-disubstituted epoxides via biocatalytic azidolysis

A practical procedure for the enzymatic resolution of 2-alkyl-2-aryl- disubstituted epoxides using the Codex HHDH P2E2 enzyme and sodium azide is reported. This method allowed the synthesis of novel regio-and enantioselective 1-azido-2-arylpropan-2-ols in

Insecticidal ethers

This invention relates to novel fluorinated ethers, useful as insecticides and acaricides, to processes and intermediates for their preparation, to insecticidal and acaricidal compositions thereof and to methods of combating and controlling insect and acarine pests therewith.