123979-16-8

Basic information

• Product Name: (S)-3-amino-3-methylpiperidine-2-one
• Synonyms: (S)-3-amino-3-methylpiperidine-2-one
• CAS NO: 123979-16-8
• Molecular Weight: 128.174
• Mol File: 123979-16-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-3-amino-3-methylpiperidine-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-amino-3-methylpiperidine-2-one(123979-16-8)
• EPA Substance Registry System: (S)-3-amino-3-methylpiperidine-2-one(123979-16-8)

Safety Data

• Hazardous Substances Data: 123979-16-8(Hazardous Substances Data)

Upstream product

• 89775-75-7 3-methyl-2-oxopiperidine-3-carboxylic acid 
• 124149-94-6 4-Cyano-2-methyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-butyric acid methyl ester 
• 81080-74-2 2-(2-cyanoethyl)alanine methyl ester 

Downstream Products

• 59574-27-5 (R)-2-methylornithin 
• 48047-95-6 α-methyl-L-ornithine 
• 1026222-44-5 3,4,5,6-tetrafluoro-N-(3-methyl-2-oxo-piperidin-3-yl)-phthalamic acid 
• 124094-97-9 N-((S)-3-Methyl-2-oxo-piperidin-3-yl)-phthalamic acid 
• 123979-17-9 N-(3-Methyl-2-oxo-piperidin-3-yl)-phthalamic acid 

Relevant articles and documents

Parallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization

By emulating the universal biosynthetic strategy, which employs modular assembly and divergent cyclizations, we have developed a four-step synthetic process to yield a collection of natural-product-inspired scaffolds. Modular assembly of building blocks onto a piperidine-based manifold 6, having a carboxylic acid group, was achieved through Ugi condensation, N-acetoacetylation and diazotransfer, leading to cyclization precursors. The rhodium-catalyzed tandem cyclization and divergent cycloaddition gave rise to tetracyclic and hexacyclic scaffolds by the appropriate choice of dipolarophiles installed at modules 3 and 4. A different piperidine-based manifold 15 bearing an amino group was successfully applied to demonstrate the flexibility and scope of the unified four-step process for the generation of structural diversity in the fused scaffolds. Evaluation of in vitro antitrypanosomal activities of the collections and preliminary structure - activity relationship (SAR) studies were also undertaken.

Syntheses of the racemates and the enantiomers of analogs of thalidomide alkylated in 3-position and determination of their absolute configuration

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