123989-28-6

Usage

Structure

Cyclopropyl derivative of propanol with a 4-chlorophenyl group attached to the first carbon and a cyclopropyl group attached to the second.

Usage

Building block in the synthesis of various pharmaceuticals and other organic compounds.

Pharmacological properties

Potential as an anticonvulsant, muscle relaxant, analgesic, and anti-inflammatory agent.

Research status

Further research is needed to fully understand its biological activities and potential applications.

Upstream product

• 123989-31-1 3-methyl-4-(4-chlorophenyl)-but-1-en-4-ol 
• 74-95-3 1,1-dibromomethane 
• 10524-06-8 (±)-(1-chloroethyl)cyclopropane 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 123989-29-7 1-(p-chlorophenyl)-2-cyclopropyl-2-methylethan-1-one 
• 94361-06-5 cyproconazol 

Relevant academic research and scientific papers

Preparation method of cyproconazole

The invention relates to a preparation method of cyproconazole as shown in the chemical structural formula I. According to the preparation method, 4-chlorobenzaldehyde is selected as a raw material to undergo a Grignard reaction to obtain a key intermediate 1-(4-chlorophenyl)-2-cyclopropyl-1-propanol; and 1-(4-chlorophenyl)-2-cyclopropyl-1-propanol undergoes an oxidation reaction, and then Sulfur ylide reaction and ring-opening reaction are successively carried out to prepare cyproconazole. Preparation reaction is as shown in the specification, wherein an oxidizing agent is selected from N-halosuccinimide, 1,3-dihalo-5,5-dimethyl hydantoin or ketone-alkoxy-aluminium; a sulfur ylide reagent is prepared by carrying out a reaction between (CH3)2S and (CH3)2SO4 under the action of KOH in isobutanol; DBU is 1,8-diazabicyalo[5.4.0]C11-7-en; and NMP is N-methylpyrrolidine.

Cyclopropane derivatives

The invention provides a process for the preparation of a compound of the general formula (I): STR1 wherein X, Y and R1 to R7 are as defined. In the process, the olefinic analog of the compound of general formula (I) is treated with a halogen-bearing compound in the presence of metallic zinc.