1239896-13-9Relevant academic research and scientific papers
Enantioselective synthesis of N–C axially chiral indoles through chiral palladium-catalyzed 5-endo-hydroaminocyclization
Morimoto, Yudai,Shimizu, Satoshi,Mokuya, Ayano,Ototake, Nobutaka,Saito, Akio,Kitagawa, Osamu
, p. 5221 - 5229 (2016/08/02)
In the presence of (R)-SEGPHOS-PdCl2catalyst, 5-endo-hydroaminocyclization of various 2-(tert-butyl)-N-(2-ethynylphenyl)anilines proceeds enantioselectively to afford optically active N–C axially chiral N-(2-tert-butylphenyl)indole derivatives
Catalytic enantioselective synthesis of atropisomeric indoles with an N-C chiral axis
Ototake, Nobutaka,Morimoto, Yudai,Mokuya, Ayano,Fukaya, Haruhiko,Shida, Yasuo,Kitagawa, Osamu
supporting information; experimental part, p. 6752 - 6755 (2010/09/07)
(Chemical Equation Presented) A pivotal role: In the presence of (R)-(-)-5,5′-bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4, 4′-bi-1,3-benzodioxole-PdCl2 [(R)-SEGPHOS-PdCl2], 5-endo-hydroaminocyclization of achiral ortho-alkynylanilines proceeds in an enantioselective manner to give optically active, axially chiral indoles (see scheme).
