1239975-70-2Relevant academic research and scientific papers
Computer-aided optimization of phosphinic inhibitors of bacterial ureases
Vassiliou, Stamatia,Kosikowska, Paulina,Grabowiecka, Agnieszka,Yiotakis, Athanasios,Kafarski, Pawe,Berlicki, Lukasz
, p. 5597 - 5606 (2010)
Urease inhibitors can be considered as a tool to control the damaging effect of ureolytic bacteria infections in humans which occur commonly in the developed countries. Computer-aided optimization of the aminomethylphosphinate structures by modifying both their N- and P-termini led to the invention of a novel group of inhibitors of bacterial ureases. Introduction of P-hydroxymethyl group into the molecule resulted in considerable increase of the inhibitory activity against enzymes purified from Bacillus pasteurii and Proteus vulgaris as compared with their P-methyl counterparts described previously. The designed compounds represent a competitive reversible class of urease inhibitors. The most potent, N-methyl-aminomethyl-P-hydroxymethylphosphinic acid, displayed Ki = 360 nM against P. vulgaris enzyme.
