1239979-07-7Relevant academic research and scientific papers
Catalytic asymmetric claisen rearrangement of unactivated allyl vinyl ethers
Geherty, Maryll E.,Dura, Robert D.,Nelson, Scott G.
supporting information; experimental part, p. 11875 - 11877 (2010/11/17)
Nearly a century after their original discovery, catalyzed enantioselective variants of the venerable Claisen rearrangement remain relatively rare. We have discovered a cooperative transition metal-Lewis acid cocatalyst system that affects highly enantio- and diastereoselective examples of archetypical Claisen rearrangements. The catalyzed rearrangements proceed using an easily prepared enantioenriched transition metal catalyst and a commercially available Lewis acid cocatalyst at ambient temperature in common solvents.
