1239986-28-7Relevant academic research and scientific papers
Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents
Dong, Yizhou,Nakagawa-Goto, Kyoko,Lai, Chin-Yu,Morris-Natschke, Susan L.,Bastow, Kenneth F.,Lee, Kuo-Hsiung
, p. 4085 - 4087 (2010)
4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs were designed, synthesized, and evaluated for cytotoxic activity. Among all 4-substituted ABO analogs, cyclohexyl (12), N-methoxy-N-methylacetamide (14), and various aromatic derivatives (15-25 and 27) exhibited promising cell growth inhibitory activity with ED50 values of 0.01-5.8 μM against all tested tumor cell lines. The 4′-methoxyphenyl derivative (18) and 3′-methylphenyl derivative (24) showed the most potent antitumor activity against a broad range of cancer cell lines with ED50 values of 0.01-76 μM. Preliminary SAR results indicated that substitutions on nitrogen are critical to the antitumor potency.
