124002-34-2Relevant academic research and scientific papers
Comparison of the inhibition of human and Trypanosoma cruzi prolyl endopeptidases
Vendeville, Sandrine,Goossens, Filip,Debreu-Fontaine, Marie-Ange,Landry, Valérie,Davioud-Charvet, Elisabeth,Grellier, Philippe,Scharpe, Simon,Sergheraert, Christian
, p. 1719 - 1729 (2002)
Prolyl endopeptidases (PEPs) have been found in numerous species. Inhibitors of human enzyme could correct cognitive deficits in Alzheimer patients while inhibition of Trypanosoma cruzi PEP could prevent invasion phase in Chagas disease. A structure-activity relationship study carried out in a tetrahydroisoquinoline series allowed to obtain potent competitive inhibitors superior to SUAM-1221. Besides, inhibitors expected to act according to an irreversible mechanism revealed to be superior to JPT-4819, for applications linked to human enzyme inhibition.
Derivatives of cyclic amino acids, agents containing them, and the use thereof
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, (2008/06/13)
The invention relates to derivatives of cyclic amino acids of the general formula STR1 in which R1 denotes hydrogen, alkyl, alkenyl or (subst.) aryl, R2 is hydrogen, alkyl, hydroxyl, alkoxy, (subst.) aryl, (subst.) aryloxy or (subst.
