1240049-64-2Relevant academic research and scientific papers
Design, synthesis, and evaluation of orally active inhibitors of plasminogen activator inhibitor-1 (PAI-1) production
Miyazaki, Hiroshi,Ogiku, Tsuyoshi,Sai, Hiroshi,Ohmizu, Hiroshi,Murakami, Jun,Ohtani, Akio
scheme or table, p. 6419 - 6422 (2009/09/06)
A novel series of butadiene-imide 1 (T-686) derivatives having an inhibitory activity against PAI-1 production was synthesized and evaluated their biological activities and DMPK profiles, in which 15k (T-2639) was selected as the best compound based on its strong antithrombotic activity and good bioavailability.
