124016-55-3Relevant academic research and scientific papers
Elaboration of vinblastine hybrids using a reactive in situ generated N-carboxyanhydride
Rannoux, Claire,Roussi, Fanny,Martin, Marie-Therese,Gueritte, Franoise
, p. 4873 - 4881 (2011/08/06)
Hybrids of vinblastine and phomopsin, designed by a molecular modelling study, were elaborated in order to target tubulin. The key step of the synthesis (fragmentation and insertion of vindoline) was mediated by an internal N-carboxyanhydride (or O-acylca
USE OF THE BARTON DECARBOXYLATION PROCEDURE IN INDOLE ALKALOID CHEMISTRY
Magnus, Philip,Ladlow, Mark,Kim, Chung Sook,Boniface, Peter
, p. 951 - 956 (2007/10/02)
L-Tryptophan was condensed with dimethyl α-ketoglutarate to give the tetracyclic amide (+) 8 and its diastereoisomer (-) 9.Conversion of (+) 8 into its derived N-hydroxy-2-thiopyridone ester 11 followed by t-butylthiol/h$v gave (+) 12.This was converted i
