124016-55-3Relevant articles and documents
Elaboration of vinblastine hybrids using a reactive in situ generated N-carboxyanhydride
Rannoux, Claire,Roussi, Fanny,Martin, Marie-Therese,Gueritte, Franoise
, p. 4873 - 4881 (2011/08/06)
Hybrids of vinblastine and phomopsin, designed by a molecular modelling study, were elaborated in order to target tubulin. The key step of the synthesis (fragmentation and insertion of vindoline) was mediated by an internal N-carboxyanhydride (or O-acylca