1240188-41-3Relevant academic research and scientific papers
Synthesis of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones as potential bioisosteres of salicylidene acylhydrazides
Hillgren, J. Mikael,Dahlgren, Markus K.,To, Tam M.,Elofsson, Mikael
experimental part, p. 6019 - 6034 (2010/11/05)
A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III secretion inhibitors.
