1240201-26-6Relevant articles and documents
An evaluation of synthetic indole derivatives as inhibitors of monoamine oxidase
Chirkova, Zhanna V.,Kabanova, Mariya V.,Filimonov, Sergey I.,Abramov, Igor G.,Petzer, Anél,Petzer, Jacobus P.,Suponitsky, Kyrill Yu.
, p. 2214 - 2219 (2016/04/20)
In a recent study we have shown that several indole-5,6-dicarbonitrile derivatives are potent inhibitors of human monoamine oxidase (MAO) A and B. To expand on these results and to further determine structure-activity relationships (SARs) for MAO inhibiti
Synthesis of 3-acyl-1-hydroxy-1H-indole-5,6-dicarbonitriles
Chirkova, Zhanna V.,Kabanova, Mariya V.,Sergeev, Sergey S.,Filimonov, Sergei I.,Abramov, Igor G.,Samet, Alexander V.,Suponitsky, Kyrill Yu.
, p. 315 - 317 (2015/08/18)
The Vilsmeier-Haack formylation of 4-(2-aryl-2-oxoethyl)-5-nitrophthalonitriles followed by reduction affords 3-acyl-1-hydroxy- 1H-indole-5,6-dicarbonitriles.
Base-induced transformations of ortho-nitrobenzylketones: Intramolecular displacement of nitro group versus nitro-nitrite rearrangement
Filimonov, Sergey I.,Chirkova, Zhanna V.,Abramov, Igor G.,Firgang, Sergey I.,Stashina, Galina A.,Strelenko, Yuri A.,Khakimov, Dmitriy V.,Pivina, Tatyana S.,Samet, Alexander V.,Suponitsky, Kyrill Yu.
, p. 5991 - 5997 (2012/09/11)
Reactions of 4-bromo-5-nitrophthalonitrile (BNPN) with enolates of alkyl 4-R-2,4-dioxobutanoates gave alkyl 3-acyl-5,6-dicyanobenzofuran-2-carboxylates, 4-(2-R-2-oxoethyl)-5-nitrophthalonitriles, or 3-acyl-1,2-benzoxazole-5,6- dicarbonitriles. With a base, 4-(2-R-2-oxoethyl)-5-nitrophthalonitriles either undergo nitro-nitrite rearrangement resulting in 3-acyl-1,2-benzoxazole-5,6- dicarbonitriles or yield 2-R-benzofuran-5,6-dicarbonitriles with a nitro group displacement.
