1240239-76-2Relevant academic research and scientific papers
Domino carbopalladation-carbonylation: Generating quaternary stereocenters while controlling β-hydride elimination
Seashore-Ludlow, Brinton,Somfai, Peter
supporting information; experimental part, p. 3732 - 3735 (2010/11/04)
A domino carbopalladation-carbonylation sequence for substrates possessing β-hydrogens is explored. This allows for the construction of complex architectures with vicinal stereocenters in a concise and rapid fashion via the stereocontrolled formation of two carbon-carbon bonds. An integral aspect of this domino reaction is the ability to control β-hydride elimination of the organopalladium intermediate and instead form the carbonylation product.
