1240264-13-4

Upstream product

• 946066-59-7 C₂₅H₂₂N₄O₄ 
• 124007-51-8 Fmoc-Val-OBt 
• 138192-08-2 (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-succinamic acid benzotriazol-1-yl ester 
• 138192-07-1 HOBt ester of Fmoc-glutamine 
• 117830-90-7 Fmoc-Asp(OtBu)-OBt 
• 117830-89-4 Fmoc-Gly-OBt 
• 117830-88-3 Fmoc-L-Ile-OBt 

Relevant academic research and scientific papers

A novel family of onium salts based upon isonitroso meldrum's acid proves useful as peptide coupling reagents

A new family of uronium salts (HTMU, HMMU, and HDmPyMU) based on isonitroso Meldrum's acid (HONM) are reported as stand-alone coupling reagents. Amide bond formation with the use of these reagents occurred more quickly than that with other uronium salts as a result of the presence of a neighboring group effect with a cyclic structure. Thus, these novel onium salts were often more effective in the acylation of poor nucleophiles and in the control of optical purity than related Oxyma- and benzotriazole-based reagents. Among the HONM derivatives, HMMU showed the best performance in reducing racemization and assembling demanding sequences such as the Aib-ACP decapeptide or analogues of Leu-enkephalin pentapeptide, Furthermore, the scope and limitations of the use of HONM as an additive in combination with carbodiimides is discussed.