124027-47-0

Basic information

• Product Name: 9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL
• Synonyms: 9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL;1-Hydroxytacrine;PD-131620
• CAS NO: 124027-47-0
• Molecular Formula: C13H14N2O
• Molecular Weight: 214.26
• Product Categories: pharmacetical
• Mol File: 124027-47-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 245℃
• Boiling Point: 450.3°Cat760mmHg
• Flash Point: 226.1°C
• Appearance: /
• Density: 1.315g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL(124027-47-0)
• EPA Substance Registry System: 9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL(124027-47-0)

Safety Data

• Hazardous Substances Data: 124027-47-0(Hazardous Substances Data)

Usage

General Description

9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL is a chemical compound with the molecular formula C13H14N2O. It is an amino derivative of acridine and contains a tetrahydroacridinol backbone. 9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL has potential pharmaceutical applications and is being studied for its medicinal properties, particularly for its potential use as an anti-tumor and anti-inflammatory agent. It is also being investigated for its potential neuroprotective and anti-Alzheimer's disease properties. Additionally, 9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL has been studied for its ability to inhibit acetylcholinesterase, an enzyme that breaks down the neurotransmitter acetylcholine, which is important for memory and cognitive function.

Upstream product

• 67-63-0 isopropyl alcohol 
• 1885-29-6 anthranilic acid nitrile 
• 104675-23-2 N-(3-oxocyclohexen-1-yl)-2-aminobenzonitrile 
• 504-02-9 1,3-cylohexanedione 
• 1684-40-8 tacrine monohydrochloride 
• 104675-26-5 9-Amino-1,2,3,4-tetrahydroacridin-1-one 

Relevant articles and documents

Simultaneous determination of tacrine and 1-hydroxy-, 2-hydroxy-, and 4- hydroxytacrine in human plasma by high-performance liquid chromatography with fluorescence detection

An analytical method was developed for the simultaneous reversed-phase (cyano) high-performance liquid chromatographic determination with fluorescence detection of tacrine and 1-hydroxy-, 2-hydroxy-, and 4- hydroxytacrine in human plasma. Alkalinized human plasma samples were extracted with a mixture of chloroform/l-propanol (90:10, v/v). Extraction recoveries generally ranged from 68% to 83% for all four compounds and did not appear to be concentration dependent over the range examined. Calibration curves were constructed over the following ranges: 0.5-30.0 ng/mL for tacrine (THA) and 4-hydroxytacrine (4-OH-THA), 1.0-30.0 ng/mL for 2-hydroxytacrine (2-OH-THA), and 0.925-46.2 ng/mL for 1-hydroxytacrine (1-OH-THA). The intra- and interassay precision (RSD) for the quality control specimens analyzed during validation were ≤11.8% and ≤9.28%, respectively. The intra- and interassay accuracy (RE) for the quality control specimens analyzed during validation ranged from 14.1% to -7.5% and 12.1% to -3.33%, respectively, for all four compounds. The limit of quantitation was estimated as the level of the lowest concentration in the calibration curve for each compound based on acceptable interassay precision and accuracy statistics generated at this concentration. The sensitivity of the method was adequate for the determination of THA, 1-OH-THA, 2-OH-THA, and 4-OH-THA following oral administration of Cognex (40 mg single dose) to normal volunteers.

Use of 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds for the treatment of aids

There is disclosed the use of 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds of the formula below, where Xis hydrogen, loweralkyl or halogen; and Ris hydrogen, loweralkyl or benzyl; for the treatment of acquired immune deficiency syndrome (AIDS).

9-Amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments

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