1240305-12-7

Basic information

• Product Name: (1S)-2,4,6-tri-O-acetyl-1-[5-({4-[(1E)-4-({1-[(2-amino-2-methylpropyl)amino]-2-methyl-1-oxopropan-2-yl}amino)-3,3-dimethyl-4-oxobut-1-en-1-yl]-2-methylphenyl}methyl)-2-methoxy-4-(propan-2-yl)phenyl]-1,5-anhydro-3-O-formyl-D-glucitol
• Synonyms: (1S)-2,4,6-tri-O-acetyl-1-[5-({4-[(1E)-4-({1-[(2-amino-2-methylpropyl)amino]-2-methyl-1-oxopropan-2-yl}amino)-3,3-dimethyl-4-oxobut-1-en-1-yl]-2-methylphenyl}methyl)-2-methoxy-4-(propan-2-yl)phenyl]-1,5-anhydro-3-O-formyl-D-glucitol
• CAS NO: 1240305-12-7
• Molecular Weight: 852.035
• Mol File: 1240305-12-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S)-2,4,6-tri-O-acetyl-1-[5-({4-[(1E)-4-({1-[(2-amino-2-methylpropyl)amino]-2-methyl-1-oxopropan-2-yl}amino)-3,3-dimethyl-4-oxobut-1-en-1-yl]-2-methylphenyl}methyl)-2-methoxy-4-(propan-2-yl)phenyl]-1,5-anhydro-3-O-formyl-D-glucitol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S)-2,4,6-tri-O-acetyl-1-[5-({4-[(1E)-4-({1-[(2-amino-2-methylpropyl)amino]-2-methyl-1-oxopropan-2-yl}amino)-3,3-dimethyl-4-oxobut-1-en-1-yl]-2-methylphenyl}methyl)-2-methoxy-4-(propan-2-yl)phenyl]-1,5-anhydro-3-O-formyl-D-glucitol(1240305-12-7)
• EPA Substance Registry System: (1S)-2,4,6-tri-O-acetyl-1-[5-({4-[(1E)-4-({1-[(2-amino-2-methylpropyl)amino]-2-methyl-1-oxopropan-2-yl}amino)-3,3-dimethyl-4-oxobut-1-en-1-yl]-2-methylphenyl}methyl)-2-methoxy-4-(propan-2-yl)phenyl]-1,5-anhydro-3-O-formyl-D-glucitol(1240305-12-7)

Safety Data

• Hazardous Substances Data: 1240305-12-7(Hazardous Substances Data)

Upstream product

• 1240304-75-9 u202fN-(2,2-dimethylbut-3-enoyl)-2-methylalanine 
• 1240304-76-0 methyl N-(2,2-dimethylbut-3-enoyl)-2-methylalaninate 
• 10276-09-2 2,2-dimethyl-but-3-enoic acid 
• 57690-96-7 2,2-dimethylbut-3-enoyl chloride 
• 1240304-71-5 (1S)-2,3,4,6-tetra-O-acetyl-1,5-anhydro-1-[5-bromo-2-methoxy-4-(propan-2-yl)phenyl]-D-glucitol 
• 1240304-70-4 (1S)-2,3,4,6-tetra-O-acetyl-1,5-anhydro-1-[2-methoxy-4-(propan-2-yl)phenyl]-D-glucitol 
• 1017608-23-9 2-iodo-5-(propan-2-yl)phenol 
• 1240304-62-4 (1S)-2,3,4,6-tetra-O-acetyl-1,5-anhydro-1-{5-[(4-bromo-2-methylphenyl)methyl]-2-methoxy-4-(propan-2-yl)phenyl}-D-glucitol 
• 1240304-73-7 C₂₄H₃₁BrO₇ 
• 1359976-25-2 C₁₇H₂₆O₇ 
• 1240304-66-8 C₂₅H₃₄O₁₁ 
• 811-93-8 1,1-dimethylethylenediamine 
• 1240304-72-6 (1S)-1,5-anhydro-1-[5-bromo-2-methoxy-4-(propan-2-yl)phenyl]-2,3,4,6-tetrakis-O-(trimethylsilyl)-D-glucitol 
• 1240304-64-6 1-iodo-2-methoxy-4-(propan-2-yl)benzene 

Downstream Products

• 1240305-13-8 (1S)-1-[5-({4-[(1E)-4-({1-[(2-amino-2-methylpropyl)amino]-2-methyl-1-oxopropan-2-yl}amino)-3,3-dimethyl-4-oxobut-1-en-1-yl]-2-methylphenyl}methyl)-2-methoxy-4-(propan-2-yl)phenyl]-1,5-anhydro-D-glucitol 

Relevant articles and documents

Discovery of potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor SGL5213 for type 2 diabetes treatment

A new series of C-phenyl D-glucitol derivatives was designed and synthesized, and their SGLT1 inhibitory potency and absorbability were evaluated. We also investigated whether kidney drug retention could be avoided by creating molecules with different excretion pathways. To achieve a class of molecules with low absorption and that were excreted in bile, optimized synthesis was performed to bring the ClogP value and the topological polar surface area to within the appropriate ranges. Compounds 34d and 34j were poorly absorbed, but the absorbed compounds were mainly excreted in bile. Thus, smaller amounts of persistent residue in the kidneys were observed. Since 34d exerted a glucose-lowering effect at a dose of 0.3 mg/kg (p.o.) in SD rats, this compound (SGL5213) could be a clinical candidate for the treatment of type 2 diabetes.