1240313-51-2Relevant academic research and scientific papers
Discovery of potent inhibitor for farnesyl pyrophosphate synthase in the mevalonate pathway
Gao, Jinbo,Chu, Xiusheng,Qiu, Yongge,Wu, Long,Qiao, Yuqin,Wu, Jiasheng,Li, Ding
supporting information; experimental part, p. 5340 - 5342 (2010/10/19)
The mevalonate pathway is an important drug target for the treatment of cancer and cardiovascular disease. We synthesized and studied a new type of nitrogen-containing bisphosphonate analogs and developed a sensitive end point assay method for enzyme FPPS, which was used for inhibitor screening. One potent FPPS inhibitor was discovered, and the structure-activity relationship of bisphosphonates for the enzyme inactivation was studied.
