1240314-58-2Relevant academic research and scientific papers
Enantioselective synthesis of polysubstituted cyclopentanones by organocatalytic double Michael addition reactions
Ma, Anqi,Ma, Dawei
, p. 3634 - 3637 (2010)
The O-TMS-protected diphenylprolinol-catalyzed cascade double Michael addition reactions of α,β-unsaturated aldehydes with a β-keto ester bearing a highly electron-deficient olefin unit occur smoothly to afford polysubstituted cyclopentanones. This process allows formation of four contiguous stereocenters in the cyclopentanone ring in one-step with excellent enantioselectivity.
