124038-37-5

Basic information

• Product Name: methyl 3-(2-oxoethyl)benzoate
• Synonyms: methyl 3-(2-oxoethyl)benzoate;(3-methoxycarbonylphenyl)acetaldehyde
• CAS NO: 124038-37-5
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178.186
• Mol File: 124038-37-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 297.1 °C at 760 mmHg
• Flash Point: 130.1 °C
• Appearance: /
• Density: 1.131
• Vapor Pressure: 0.00138mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: methyl 3-(2-oxoethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(2-oxoethyl)benzoate(124038-37-5)
• EPA Substance Registry System: methyl 3-(2-oxoethyl)benzoate(124038-37-5)

Safety Data

• Hazardous Substances Data: 124038-37-5(Hazardous Substances Data)

Usage

General Description

Methyl 3-(2-oxoethyl)benzoate, also known as ethyl 3-formylbenzoate, is an organic compound with the chemical formula C10H10O4. It is an ester, commonly used in the synthesis of various pharmaceuticals, fragrances, and other organic compounds. Methyl 3-(2-oxoethyl)benzoate is a colorless liquid with a fruity odor, and it is insoluble in water but soluble in organic solvents. It is often used as a flavoring agent in food and beverages, and it has also been studied for its potential medical applications, such as its anti-inflammatory and anti-cancer properties. However, it is important to handle this compound with care, as it may be hazardous if not used properly.

InChI:InChI=1/C10H10O3/c1-13-10(12)9-4-2-3-8(7-9)5-6-11/h2-4,6-7H,5H2,1H3

Upstream product

• 91-22-5 quinoline 
• 898767-05-0 3-(1,3-dioxolan-2-ylmethyl)benzoic acid 
• 52178-50-4 Methyl 3-formylbenzoate 
• 816449-73-7 3-(2-methoxy-vinyl)-benzoic acid methyl ester 

Downstream Products

• 153599-45-2 methyl 3-(2-hydroxylethyl)benzoate 
• 1354804-44-6 3-{2-[9-(3-fluorobenzyl)-5,6,8,9-tetrahydro-7H-pyrido[4',3':4,5]pyrrolo[2,3-b]pyridin-7-yl]-2-oxoethyl}benzoic acid 
• 52787-19-6 2-(3-(methoxycarbonyl)phenyl) acetic acid 

Relevant articles and documents

ONO-8430506: A Novel Autotaxin Inhibitor That Enhances the Antitumor Effect of Paclitaxel in a Breast Cancer Model

Lysophosphatidic acid (LPA) is a bioactive lipid mediator that elicits a number of biological functions, including smooth muscle contraction, cell motility, proliferation, and morphological change. LPA is endogenously produced by autotaxin (ATX) from extracellular lysophosphatidylcholine (LPC) in plasma. Herein, we report our medicinal chemistry effort to identify a novel and highly potent ATX inhibitor, ONO-8430506 (20), with good oral availability. To enhance the enzymatic ATX inhibitory activity, we designed several compounds by structurally comparing our hit compound with the endogenous ligand LPC. Further optimization to improve the pharmacokinetic profile and enhance the ATX inhibitory activity in human plasma resulted in the identification of ONO-8430506 (20), which enhanced the antitumor effect of paclitaxel in a breast cancer model.

FXR AGONISTS

Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.

Diarylstrylquinoline diacids and pharmaceutical compositions thereof

Compounds having the formula: STR1 are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents.