1240388-74-2Relevant academic research and scientific papers
Gold(I) - Catalyzed domino reaction of aziridinyl alkynes
Zhang, Zhen,Shi, Min
supporting information; experimental part, p. 7725 - 7729 (2010/09/10)
Chemical Equation Presented Aziridinyl alkynes strike gold: A novel gold(I)-catalyzed domino transformation of aziridinyl alkynes with arenes to construct 1,2,3,4-tetrahydroisoquinoline and 3,4-dihydroisoquinoline structural motifs (see scheme), especially sterically congested Syn-3,4-disubsti contzonetuted 1,2,3,4-tetrahydroisoquinolines, is described. A plausible mechanism proceeding through a benzylic cation is given based upon deuterium-labeling and control experiments as well as the observed diastereoselectivities.
